The presenter who had been with the English-speaking channel for years, announced the news on social media, Monday evening.
Posting a picture of himself and co-host Jessica Saforo on Facebook, the on-air personality said: "Throw back to when we started this tag team. 7 years on radio ended today. I'll miss you Akua Jessica OS and everyone else. It'll always be home. New Journey begins."
It is unclear where Osei Kwame heads next.
His exit comes barely three months after DJ Armani left the station having served for 11 years.
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